We are pleased to share our latest publication in BIOCELL, where we report that butyrophilin (BTN) genes—key regulators of γδ T cell activity—are significantly downregulated in chronic lymphocytic leukemia (CLL). Our analysis of public RNA-seq and microarray datasets reveals that reduced expression of BTN2A1, BTN3A1, BTN3A2, and BTN3A3 in CLL may impair γδ T cell-mediated immune responses.
Importantly, we found that lower BTN expression correlates with unmutated IGVH status, male sex, and poorer overall survival—highlighting the potential prognostic value of BTN profiling. These insights bring us closer to understanding γδ T cell exhaustion in CLL and open new avenues for biomarker development and immune-based therapies.
You can access the full article here.
