{"id":141,"date":"2024-06-28T14:13:38","date_gmt":"2024-06-28T14:13:38","guid":{"rendered":"http:\/\/www.gammadelta.pl\/?p=141"},"modified":"2024-06-28T14:15:39","modified_gmt":"2024-06-28T14:15:39","slug":"gd-t-cells-in-chronic-lymphocytic-leukaemia-new-article-published","status":"publish","type":"post","link":"http:\/\/www.gammadelta.pl\/index.php\/2024\/06\/28\/gd-t-cells-in-chronic-lymphocytic-leukaemia-new-article-published\/","title":{"rendered":"\u03b3\u03b4 T cells in chronic lymphocytic leukaemia &#8211; new article published"},"content":{"rendered":"\n<p>We have recently published a new article about \u03b3\u03b4 T cells in chronic lymphocytic leukaemia. For the full article please click <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.17219\/acem\/186335\" data-type=\"URL\" data-id=\"https:\/\/doi.org\/10.17219\/acem\/186335\" target=\"_blank\">here<\/a>. We observed a dysregulation of CD155 &#8211; TIGIT\/DNAM-1 pathway. While CD226 (DNAM-1) was decreased on \u03b3\u03b4 T, TIGIT had higher expression. At the same time, CD155, a ligand of both DNAM-1 and TIGIT, was significantly overexpressed by leukaemic cells. Altogether this suggests a possible usefulness of TIGIT inhibitors as future therapeutics in chronic lymphocytic leukaemia.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>We have recently published a new article about \u03b3\u03b4 T cells in chronic lymphocytic leukaemia. For the full article please click here. We observed a dysregulation of CD155 &#8211; TIGIT\/DNAM-1 pathway. While CD226 (DNAM-1) was decreased on \u03b3\u03b4 T, TIGIT had higher expression. At the same time, CD155, a ligand of both DNAM-1 and TIGIT, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[26,23,28,27,24,25,22,21,20],"_links":{"self":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/141"}],"collection":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/comments?post=141"}],"version-history":[{"count":1,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/141\/revisions"}],"predecessor-version":[{"id":142,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/141\/revisions\/142"}],"wp:attachment":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/media?parent=141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/categories?post=141"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/tags?post=141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}