{"id":202,"date":"2025-05-21T13:42:55","date_gmt":"2025-05-21T13:42:55","guid":{"rendered":"https:\/\/www.gammadelta.pl\/?p=202"},"modified":"2025-05-21T13:43:17","modified_gmt":"2025-05-21T13:43:17","slug":"our-new-findings-on-butyrophilin-downregulation-and-gd-t-cell-dysfunction-in-cll","status":"publish","type":"post","link":"http:\/\/www.gammadelta.pl\/index.php\/2025\/05\/21\/our-new-findings-on-butyrophilin-downregulation-and-gd-t-cell-dysfunction-in-cll\/","title":{"rendered":"Our New Findings on Butyrophilin Downregulation and \u03b3\u03b4 T Cell Dysfunction in CLL"},"content":{"rendered":"\n<p>We are pleased to share our latest publication in <em>BIOCELL<\/em>, where we report that butyrophilin (BTN) genes\u2014key regulators of \u03b3\u03b4 T cell activity\u2014are significantly downregulated in chronic lymphocytic leukemia (CLL). Our analysis of public RNA-seq and microarray datasets reveals that reduced expression of BTN2A1, BTN3A1, BTN3A2, and BTN3A3 in CLL may impair \u03b3\u03b4 T cell-mediated immune responses.<\/p>\n\n\n\n<p>Importantly, we found that lower BTN expression correlates with unmutated IGVH status, male sex, and poorer overall survival\u2014highlighting the potential prognostic value of BTN profiling. These insights bring us closer to understanding \u03b3\u03b4 T cell exhaustion in CLL and open new avenues for biomarker development and immune-based therapies.<\/p>\n\n\n\n<p>You can access the full article <a class=\"\" href=\"https:\/\/doi.org\/10.32604\/biocell.2025.063960\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are pleased to share our latest publication in BIOCELL, where we report that butyrophilin (BTN) genes\u2014key regulators of \u03b3\u03b4 T cell activity\u2014are significantly downregulated in chronic lymphocytic leukemia (CLL). Our analysis of public RNA-seq and microarray datasets reveals that reduced expression of BTN2A1, BTN3A1, BTN3A2, and BTN3A3 in CLL may impair \u03b3\u03b4 T cell-mediated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[20],"_links":{"self":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/202"}],"collection":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/comments?post=202"}],"version-history":[{"count":1,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/202\/revisions"}],"predecessor-version":[{"id":203,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/posts\/202\/revisions\/203"}],"wp:attachment":[{"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/media?parent=202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/categories?post=202"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.gammadelta.pl\/index.php\/wp-json\/wp\/v2\/tags?post=202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}